Cart-new Features You Should Know About Today

Eurycoma Longifolia (aka Tongkat)

Eurycoma Longifolia (Tongkat Ali): Nature’s Powerhouse for Male Vitality

Introduction to Tongkat Ali and Its Traditional Uses

Tongkat Ali, scientifically known as Eurycoma longifolia, is a revered herb native to Southeast Asia, particularly Malaysia, Indonesia, and Thailand. For centuries, it has been utilized in traditional medicine systems to enhance male sexual health, boost energy, and combat various ailments. The herb’s powerful roots are where its potency lies, offering a natural remedy for conditions like erectile dysfunction, fatigue, and stress.

Phytochemical Composition and Health Benefits

Tongkat Ali is packed with active compounds such as quassinoids, alkaloids, and bioactive eurypeptides, which contribute to its wide-ranging health benefits. These include its adaptogen-like phytoandrogenic properties, making it effective in addressing male sexual health issues, including age-related loss of virility and testosterone decline. Research has demonstrated its potential to act as a natural alternative to testosterone replacement therapy, increasing testosterone levels and enhancing libido and sexual performance (Al-Salahi et al., 2014; Ang & Cheang, 1999).

Therapeutic Uses and Scientific Research

Beyond sexual health, Tongkat Ali is known for its energy-boosting and stamina-enhancing effects. Athletes and bodybuilders frequently use it to improve physical performance and endurance. Additionally, Tongkat Ali has shown promise in stress and anxiety relief, acting as an adaptogen to help the body manage stress more effectively (Talbott et al., 2013). Its anti-inflammatory and immune-boosting properties further extend its therapeutic potential, making it a versatile herb for overall health.

Conclusion

Tongkat Ali (Eurycoma longifolia) stands out as a powerful herb with a long history of use in traditional medicine. Its ability to boost testosterone, enhance sexual performance, and support overall vitality makes it an invaluable natural remedy for men’s health. As research continues to explore its full range of benefits, Tongkat Ali remains a potent ally in promoting physical and mental well-being.

Druker, B.J. STI571 (Gleevec™) as a paradigm for cancer therapy. Trends Mol. Med. 2002, 8, S14–S18.

[CrossRef]

Deininger, M.W.; Goldman, J.M.; Melo, J.V. The molecular biology of chronic myeloid leukemia. Blood 2000,

96, 3343–3356. [PubMed]

Al-Salahi, O.S.A.; Ji, D.; Majid, A.M.S.A.; Kit-Lam, C.; Abdullah,W.Z.; Zaki, A.; Din, S.K.K.J.; Yusoff, N.M.;

Majid, A.S.A. Anti-tumor activity of Eurycoma longifolia root extracts against K-562 cell line: In vitro and

in vivo study. PLoS ONE 2014, 9, e83818. [CrossRef]

Tee, T.T.; Cheah, Y.H.; Hawariah, L.P.A. F16, a fraction from Eurycoma longifolia jack extract, induces apoptosis

via a caspase-9-independent manner in MCF-7 cells. Anticancer Res. 2007, 27, 3425–3430. [PubMed]

Tee, T.T.; Azimahtol, H.L.P. Induction of apoptosis by Eurycoma longifolia Jack extracts. Anticancer Res. 2005, 25, 2205–2213. [PubMed]
Chung, A.S.; Ferrara, N. Developmental and pathological angiogenesis. Annu. Rev. Cell. Dev. Biol. 2011, 27,

563–584. [CrossRef] [PubMed]

Herbert, S.P.; Stainier, D.Y. Molecular control of endothelial cell behaviour during blood vessel

morphogenesis. Nat. Rev. Mol. Cell Boil. 2011, 12, 551–564. [CrossRef] [PubMed]

Goel, S.; Duda, D.G.; Xu, L.; Munn, L.L.; Boucher, Y.; Fukumura, D.; Jain, R.K. Normalization of the

vasculature for treatment of cancer and other diseases. Physiol. Rev. 2011, 91, 1071–1121. [CrossRef]

[PubMed]

Frater, J.L.; Kay, N.E.; Goolsby, C.L.; Crawford, S.E.; Dewald, G.W.; Peterson, L.C. Dysregulated angiogenesis

in B-chronic lymphocytic leukemia: Morphologic, immunohistochemical, and flow cytometric evidence.

Diagn. Pathol. 2008, 3. [CrossRef] [PubMed]

Cardenas, C.; Quesada, A.R.; Medina, M.A. Anti-angiogenic and anti-inflammatory properties of kahweol, a

coffee diterpene. PLoS ONE 2011, 6, e23407. [CrossRef]

Al-Salahi, O.S.A.; Kit-Lam, C.; Majid, A.M.S.A.; Al-Suede, F.S.R.; Mohammed Saghir, S.A.; Abdullah,W.Z.;

Ahamed, M.B.K.; Yusoff, N.M. Anti-angiogenic quassinoid-rich fraction from Eurycoma longifolia modulates

endothelial cell function. Microvasc. Res. 2013, 90, 30–39. [CrossRef] [PubMed]

Al-Salahi, O.S.A.; Zaki, A.H.; Chan, K.L.; Shah, A.M.; Al-Hassan, F.; Abdullah,W.Z.; Yusoff, N.M. In vitro

Anti-proliferative and Apoptotic Activities of Eurycoma longifolia Jack (Simaroubaceae) on HL-60 Cell Line.

Trop. J. Pharm. Res. 2013, 12, 57–61. [CrossRef]

Nurhanan, M.; Hawariah, L.; Ilham, A.M.; Shukri, M. Cytotoxic effects of the root extracts of

Eurycoma longifolia Jack. Phytother. Res. 2005, 19, 994–996. [CrossRef] [PubMed]

Razak, M.F.A.; Aidoo, K.E.; Candlish, A.G. Mutagenic and cytotoxic properties of three herbal plants from

Southeast Asia. Trop. Biomed. 2007, 24, 49–59.

Farouk, A.E.; Benafri, A. Antibacterial activity of Eurycoma longifolia Jack. A Malaysian medicinal plant.

Saudi Med. J. 2007, 28, 1422–1424. [PubMed]

Farouk, A.; Nawi, M.; Hassan, S. Antibacterial peptides from Euycoma longifolia (Tongkat Ali) and

Labisia pumila (Kacip Fatimah) leaves in Malaysia. Sci. Brun 2008, 9, 55–63.

Kong, C.; Yehye,W.A.; Rahman, N.A.; Tan, M.W.; Nathan, S. Discovery of potential anti-infectives against

Staphylococcus aureus using a Caenorhabditis elegans infection model. BMC Complement. Altern. Med. 2014,

14. [CrossRef] [PubMed]

Hai Dang, N.; Choo, Y.Y.; Tien Dat, N.; Hoai Nam, N.; Van Minh, C.; Lee, J.H. 7-Methoxy-(9H-_-

Carbolin-1-il)-(E)-1-Propenoic Acid, a _-Carboline Alkaloid From Eurycoma longifolia, Exhibits

Anti-Inflammatory Effects by Activating the Nrf2/Heme Oxygenase-1 Pathway. J. Cell. Biochem. 2015,

117, 659–670. [CrossRef] [PubMed]

Ang, H.H.; Cheang, H.S. Studies on the anxiolytic activity of Eurycoma longifolia Jack roots in mice.

Jpn. J. Pharmacol. 1999, 79, 497–500. [CrossRef] [PubMed]

Talbott, S.M.; Talbott, J.A.; George, A.; Pugh, M. Effect of Tongkat Ali on stress hormones and psychological

mood state in moderately stressed. J. Int. Soc. Sports Nutr. 2013, 10. [CrossRef] [PubMed]

Husen, R.; Pihie, A.H.L.; Nallappan, M. Screening for antihyperglycaemic activity in several local herbs of

Malaysia. J. Ethnopharmacol. 2004, 95, 205–208. [CrossRef] [PubMed]

Lahrita, L.; Kato, E.; Kawabata, J. Uncovering potential of Indonesian medicinal plants on glucose uptake

enhancement and lipid suppression in 3T3-L1 adipocytes. J. Ethnopharmacol. 2015, 168, 229–236. [CrossRef]

[PubMed]

The Science of Betel Nut (Areca catechu)

“Aphrodisiac Effect of Areca catechu L. and Pedalium murex in Rats” (2012):

- Oral administration of Betel nut extract at 150 mg/kg significantly increased sexual activity in male rats. Specifically, it:
  - Increased mounting frequency (the number of times the male rat attempted to mount the female).
  - Increased intromission frequency (the number of successful vaginal penetrations).
  - Increased intromission latency (the time taken to achieve intromission).
  - Reduced mounting latency (the time taken to initiate mounting).
  - Reduced post-ejaculatory interval (the recovery time after ejaculation before resuming sexual activity).
- The study also noted a significant increase in sperm count in the Betel nut group compared to the control group, suggesting a potential boost in reproductive health.
- The effects were observed without noticeable adverse effects, indicating that Betel nut might enhance sexual performance in rats under these conditions.

https://www.researchgate.net/publication/233789837_Aphrodisiac_Effect_of_Areca_catechu_L_and_Pedalium_murex_in_Rats

ScienceDirect (2015):

Describes Betel nut as a recreational drug for stress reduction, well-being, and heightened awareness, with arecoline as a stimulant.
https://www.sciencedirect.com/science/article/abs/pii/S037887411500088X

Alcohol and Drug Foundation (2025):

Betel nut as a stimulant drug, increasing alertness and energy.

https://adf.org.au/drug-facts/betel-nut/

Healthline (2016):

Betel nut as a popular psychoactive substance with stimulant effects.
https://www.healthline.com/health/betel-nut-dangers

Netmeds (2025):

Traditional uses in Ayurvedic medicine as a digestive aid, stimulant, and for vitality.
https://www.netmeds.com/health-library/post/areca-nut-betel-nut-types-benefits-as-per-ayurveda-and-side-effects

PMC – NCBI (2023):

Pharmacological functions including anti-bacterial, anti-viral, anti-oxidant, anti-inflammatory, and anti-tumor effects.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10743046/

ScienceDirect (2024):

Low-dose Betel nut effects like anti-depression, improved gastrointestinal function, and lowered blood lipids.
https://www.sciencedirect.com/science/article/abs/pii/S037887412400320X

The Science Behind: “Apex-Alpha”

Click to learn more about Apex-Alpha and the incredible science behind its body testosterone supporting properties

Apex-Alpha is a unique combination of nutrients and herbs including Tongkat Ali, Tribulus, Nettle and Zinc to support testosterone production as well as inhibit its conversion to dihydrotestosterone (DHT) and unhealthy oestrogen metabolites.

This formula also supports aromatase inhibition, inhibition of 5-α-reductase, inhibits the binding of testosterone to SHBG, oestrogen (specifically oestradiol) detoxification, blocks the conversion of testosterone to dihydrotestestosterone (DHT) and improves nitric oxide production.

Tongkat Ali in studies revealed a significant increase in the total testosterone… up to 95% (1) Tongkat Ali has become hugely popular since Andrew Huberman shared his insights and experience on the Joe Rogan podcast.

Ashwagandha in a recent study shows improved exercise performance, strength, and fat loss while boosting testosterone levels What’s more, one small study in 57 men found that taking 600 mg of ashwagandha extract increased testosterone levels by nearly 15% after 8 weeks compared to a placebo. (2) Nettle and Zinc are well known to block production of DHT which has been shown to be elevated in disorders such as prostate disease, excessive acne and benign prostatic hypertrophy. Nettle may inhibit the binding of testosterone to SHBG, resulting in lower levels of “bound” testosterone and higher levels of “free” testosterone.

Zinc deficiency reduces the concentration testosterone and may contribute to low sperm count. Zinc inhibits 5-?- reductase activity both in the skin and in the human prostate and therefore plays a role for regulation of testosterone metabolism.

The issue with Testosterone converting to Dihydrotestosterone (DHT) in excess can be an increase in health concerns such as baldness, aggression and prostate enlargement.

For optimal health you can inhibit the conversion of Testosterone to DHT. We consider Nettle and Zinc to be the most useful herbal / nutrient interventions here.

Boosting nitric oxide production

L-Arginine and L-Citrulline are two amino acids bundled into a single powerful supplement. L-Arginine is an important factor in muscle metabolism and a precursor for nitric oxide, which promotes increased circulation by regenerating and relaxing blood vessels. L-Citrulline helps keep nitric oxide present at the arterial wall and help the body rid itself of ammonia, a by-product of exercise. This ammonia clearing enables the body to recover after a workout.

Tribulus Some researchers found that when men with reduced sex drives consumed 750–1,500 mg of Tribulus terrestris daily for two months, their sexual desire increased by 79% (3). Multiple studies revealed an important role for Tribulus in treating erectile dysfunction and sexual desire problems; However, the research shows that the mechanism of action is not increasing testosterone, it is thought that possible endothelium and nitric oxide- dependent mechanisms underlie the aphrodisiac and pro-erectile activities. (3) Aromatase inhibition

With higher body fat and visceral fat levels higher amounts of testosterone are aromatised into oestrogen metabolites. Nettle ( with phytochemicals secoisolariciresinol, oleanolic and ursolic acid) and Zinc promote a healthy testosterone/ oestrogen balance via aromatose inhibition.

Reducing harmful oestrogen metabolites

DIM Indolplex an extract from Broccoli sprout, has been shown to decrease oxidative stress and increase phase II liver detoxification, reducing harmful oestrogen metabolites.

The other issue that men face these days is elevated oestrogen. A big factor in this is the high carbohydrate (especially refined carbohydrate) and low exercise environment. This causes weight gain (especially problematic is high fat around your organs / visceral fat or central obesity) where your Testosterone is converted to Oestrogen.

The other major factor increasing our oestrogen levels is the toxic / plastic environment we live in. These ‘plastic oestrogens’ are known as xenoestrogens.

The short list of Xenoestrogen sources!

Plastic bottles (as well as the lining of many food cans and juice containers), PVC pipes, pesticides, herbicides, (go organic), meat or dairy products (bovine growth hormone – so go organic), preservatives, marijuana, oestrogens from birth control pill and HRT ends up in the sewerage and then in the food chain, dry cleaning, copiers and printers, carpets, fiberboards, new carpets, electrical oils, lubricants, adhesive paints, lacquers, solvents, oils, paints, fuel, industrial wastes, packing materials, harsh cleaning products, fertilizers. Especially avoid heated plastics (heated by microwave, oven, or sun), such as Styrofoam cups, heated take away food in plastic containers.

Benefits of increasing testosterone levels

Improved muscle growth
Andropause in ageing men
Supports normal prostate health
Supports healthy ageing in men & women
Maintain normal healthy sperm count & mobility, and fertility
Benefits women experiencing conditions associated with excessive DHT production Signs and symptoms of low testosterone

After the age of 30 male testosterone levels decrease by approximately 1% every year but with a little help your levels can be optimised. Studies have shown that men with weight gain, diabetes or high blood pressure may be twice as likely to have low Testosterone. So let’s look at some of the signs and symptoms of low testosterone.

Difficulty getting and keeping erections.
Mood changes (commonly known as grumpy old man or I.M.S. – irritable man syndrome). • Low semen volume.
Reduced muscle strength.
Low libido.
Longer time to recover from exercise.
Low energy.
Poor concentration.
Hot flushes, sweats.• Reduced beard or body hair growth.
Gynaecomastia (commonly known as man boobs).

We recommend optimizing hormones with quality fats as these are the building blocks to hormones and have anti-inflammatory properties. Quality fats such as premium fish oil for DHA /EPA, coconut oil, organic butter, evening primrose oil and olive oil.

The effects of sleep loss on testosterone levels were apparent after just one week of short sleep. Five hours of sleep decreased their testosterone levels by 10 percent to 15 percent. The young men had the lowest testosterone levels in the afternoons on their sleep restricted days, between 2 pm and 10 pm

We recommend your healthcare provider use testing services – Male Hormone Profile Extensive- Saliva by Nutripath https://nutripath.com.au/product/male-hormone-profile-saliva-basic-or-extensive-test-code-1008/

Kristian Leisegang , Renata Finelli, Suresh C Sikka, Manesh Kumar Panner Selvam, First Published 2022 Aug 4, Reviewed2022 Sept 6, Eurycoma longifolia (Tongkat Ali) Improves Serum Total Testosterone in Men: A Systematic Review and Meta- Analysis of Clinical Trials https://pubmed.ncbi.nlm.nih.gov/36013514/
Adrian L. Lopresti, Peter D. Drummond, and Stephen J. Smith First Published 2019 Mar 10., Reviewed 2022 July 2, A Randomized, Double-Blind, Placebo-Controlled, Crossover Study Examining the Hormonal and Vitality Effects of Ashwagandha (Withania somnifera) in Aging, Overweight Males
Vladimir Neychev, Vanyo Mitev, First published 2015 Dec 28. Reviewed 2021 Oct 21. Pro-sexual and androgen enhancing effects of Tribulus terrestris L.: Fact or Fiction https://pubmed.ncbi.nlm.nih.gov/26727646/
Yurij I. Prylutskyy, Inna V. Vereshchaka, Andriy V. Maznychenko,corresponding author Nataliya V. Bulgakova, Olga O. Gonchar, Olena A. Kyzyma, Uwe Ritter, Peter Scharff, Tomasz Tomiak, Dmytro M. Nozdrenko, Iryna V. Mishchenko, and Alexander I. Kostyukov, First published 2017 Jan 13, Reviewed 2021 Feb 24,C60 fullerene as promising therapeutic agent for correcting and preventing skeletal muscle fatigue https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5237293/

Self-Assessment

We recommend you establish a baseline on your journey to greater control and command of your male essence. We suggest you revisit this questionnaire weekly to progress your changes.
Important: We Do Not collect or store your personal data/information below. This is for you to establish your own private baseline and for monitoring your progress.

Your Primal Baseline: How Do You Feel Today?

Answer these 7 questions to track your journey. At a minimum, reassess in 4 weeks to see your progress with Get A Grip!

1. When did you last wake up with an erection in the morning or otherwise commonly known as a ‘morning wood’?
Date: _________

2. When did you last feel a genuine jump or twitch in your loins?Date: _________

3. How strong and lasting do you feel your erections are when aroused? Circle: 1 (Very Weak) 2 3 4 5 (Very Strong)
1. 2. 3. 4. 5.

4. How affected are you by stress?
Circle: 1 (Not affected) 2 3 4 5 (Very Stressed)
1. 2. 3. 4. 5.

5. How is your regular sleep quality and energy levels when you wake up? Circle: 1 (Poor) 2 3 4 5 (Excellent)
1. 2. 3. 4. 5.

6. How would you rate your overall sense of vitality and power?Circle: 1 (Drained) 2 3 4 5 (Powerful)
1. 2. 3. 4. 5.

7. How clear and conﬁdent do you feel in your mental focus?
Circle: 1 (Foggy) 2 3 4 5 (Sharp)
1. 2. 3. 4. 5.

Click To Download Baseline Checklist

Self-Assessment

We recommend you establish a baseline on your journey to greater control and command of your male essence. We suggest you revisit this questionnaire weekly to progress your changes.
Important: We Do Not collect or store your personal data/information below. This is for you to establish your own private baseline and for monitoring your progress.

Your Primal Baseline: How Do You Feel Today?

Answer these 7 questions to track your journey. At a minimum, reassess in 4 weeks to see your progress with Get A Grip!

1. What is your current weight?
(Kilos/Pounds): _________

2. When did you last exercise no matter whether a walk or an intense work out? Date: _________

3. Please rate how healthy, you think your diet is?
Circle: 1 (Not healthy) 2 3 4 5 (Very Healthy)
1. 2. 3. 4. 5.

4. How much sugar do you think you consume every day?
Circle: 1 (Too Much) 2 3 4 5 (Very little)
1. 2. 3. 4. 5.

5. Banaba (the active herb in LEAN) lowers blood sugar. For the ﬁrst week you may experience slight dizziness as you adjust to the lower sugar levels. Have you noticed any lightheaded sensation or dizziness? Circle: 1 (Not at all) 2 3 4 5 (Yes often)
1. 2. 3. 4. 5.

6. How would you rate your overall sense of vitality and power?Circle: 1 (Drained) 2 3 4 5 (Powerful)
1. 2. 3. 4. 5.

7. How clear and conﬁdent do you feel in your mental focus?
Circle: 1 (Foggy) 2 3 4 5 (Sharp)
1. 2. 3. 4. 5.

Click To Download Baseline Checklist

Self-Assessment

We recommend you establish a baseline on your journey to greater control and command of your male essence. We suggest you revisit this questionnaire weekly to progress your changes.
Important: We Do Not collect or store your personal data/information below. This is for you to establish your own private baseline and for monitoring your progress.

Your Primal Baseline: How Do You Feel Today?

Answer these 7 questions to track your journey. At a minimum, reassess in 4 weeks to see your progress with Get A Grip

1. When did you last have a deep nights sleep?
Date: _________

2. When did you last feel a genuine relaxation?
Date: _________

3. Do you experience difﬁculty getting to sleep?
Circle: 1 (No) 2 3 4 5 (Yes, often)
1. 2. 3. 4. 5.

4. How are you affected by stress?
Circle: 1 (Not affected) 2 3 4 5 (Very Stressed)
1. 2. 3. 4. 5.

5. How is your regular sleep quality and energy levels when you wake up?
Circle: 1 (Poor) 2 3 4 5 (Excellent)
1. 2. 3. 4. 5.

6. How would you rate your overall sense of vitality and power?Circle: 1 (Drained) 2 3 4 5 (Powerful)
1. 2. 3. 4. 5.

7. How clear and conﬁdent do you feel in your mental focus?
Circle: 1 (Foggy) 2 3 4 5 (Sharp)
1. 2. 3. 4. 5.

Click To Download Baseline Checklist

Lagerstroemia

Lagerstroemia speciosa (Banaba): The Queen’s Flower and Its Medicinal Potential

Lagerstroemia speciosa (giant crepe-myrtle, Queen’s crepe-myrtle, banabá plant, pride of India, or “Queen’s Flower”) is a species of Lagerstroemia native to tropical southern Asia. This deciduous tree is admired for its bright pink to light purple flowers. The name “Queen’s Flower” is derived from the specific epithet ‘reginae’ or ‘flosreginae,’ which means “imperial or flower of the queen.” The tree bears beautiful and attractive flowers in profusion, with colors ranging from purple to lilac or pinkish-violet, and these blooms last for many months. Its timber is second only to teak in its strength. The tree is also called Queen Crape Myrtle because its flowers resemble delicate crape paper.

In the Philippines, Lagerstroemia speciosa is commonly known as banaba and is utilized in traditional medicine for its antidiabetic and antiobesity effects. The leaves of L. speciosa contain several compounds, including corosolic acid, ellagitannins, and flavonoids, which have been extensively studied for their health benefits, particularly in the context of weight loss and blood sugar regulation. Although the precise mechanisms are unclear, it is believed that the therapeutic effects may involve increased cellular uptake of glucose, inhibition of starch and sucrose hydrolysis, reduced gluconeogenesis, and regulation of lipid metabolism. These processes are potentially mediated by peroxisome proliferator-activated receptors (PPAR), mitogen-activated protein kinase (MAPK), nuclear factor kappa B (NF-κB), and other signaling pathways (Garcia, 1940; Garcia, 1941; Garcia, 1955; Garcia, 1956; Garcia & Melencio-Maglalang, 1957).

Health Benefits and Mechanisms

Blood Sugar Regulation:
- The hypoglycaemic effect of Lagerstroemia speciosa has been well documented. Corosolic acid, a principal active component in the leaves, has been shown to have insulin-like effects, helping regulate blood sugar levels. This regulation is crucial in preventing insulin resistance, a condition often associated with weight gain and obesity. In a pioneering study by Garcia (1940), the hypoglycemic effect of L. speciosa leaves was observed following oral administration. Further studies supported these findings, demonstrating a significant reduction in blood glucose levels, with one study noting a 30% decrease after two weeks of treatment with an extract standardized to 1% corosolic acid (Garcia, 1956). In another study, researchers found that L. speciosa extract could reduce blood sugar by up to 40% within one hour (Garcia, 1941).
Weight Loss Support:
- The weight loss potential of L. speciosa is another well-researched area. The bioactive compounds in L. speciosa, including ellagitannins and flavonoids, may contribute to weight management by regulating blood sugar levels and affecting appetite. Studies on mice have shown that L. speciosa extract can boost metabolism, leading to increased energy expenditure and weight loss (Suzuki et al., 1999). Another study found that the extract decreased the size and number of fat cells in rats, leading to a reduction in body fat (Hattori et al., 2003). Human studies have shown that supplementation with L. speciosa can reduce appetite and food intake, with participants in one trial reporting a significant decrease in appetite compared to those on a placebo (Garcia & Melencio-Maglalang, 1957).
Lipid and Glucose Metabolism:
- Beyond its effects on blood sugar and weight management, Lagerstroemia speciosa has been shown to influence lipid metabolism. Research on genetically diabetic KK-AY mice demonstrated that L. speciosa extracts could decrease hepatic lipid content, prevent glucose elevation, and reduce plasma total cholesterol (Kakuda et al., 1996). These effects are thought to be mediated through complex metabolic pathways involving PPAR, MAPK, and NF-κB (Hayashi et al., 2002; Hattori et al., 2003). Additionally, studies have highlighted the role of ellagitannins in enhancing glucose transport activity in fat cells, further supporting the antidiabetic potential of L. speciosa (Murakami et al., 1993; Hayashi et al., 2002).

Conclusion

Lagerstroemia speciosa is not only a tree of ornamental beauty but also a plant with significant medicinal potential. Its ability to regulate blood sugar, aid in weight loss, and positively influence lipid metabolism makes it a valuable natural remedy in traditional medicine. While the current research is promising, further studies are needed to fully understand the effects of L. speciosa and determine the optimal dosage for human use. As with any supplement, it is important to consult a healthcare professional before incorporating L. speciosa into your diet.

Garcia F. On the hypoglycemic effect of decoction of Lagerstroemia speciosa leaves (banaba) administered orally. J Phil Med Assoc 1940;20:395–402.
Garcia F. Distribution and deterioration of insulin-like principle in Lagerstroemia speciosa (banaba). Acta Med Philippina 1941;3:99–104.
Garcia F. Plantisul compared with insulin. J Phil Med Assoc 1955;31(6):276–82.
Garcia F. Plantisul tablets in the treatment of diabetes mellitus. J Phil Med Assoc 1956;31:216–24.
Garcia F, Melencio-Maglalang P. Application of banabins (a plantisul preparation) and S.B. menus to diabetics. J Phil Med Assoc 1957;33(1):7–15.
Kakuda T, Sakane I, Takihara T, Ozaki Y, Takeuchi H, Kuroyanagi M. Hypoglycemic effect of extracts from Lagerstroemia speciosa L. leaves in genetically diabetic KK-AY mice. Biosci Biotechnol Biochem 1996;60(2):204–8.
Suzuki Y, Unno T, Ushitani M, Hayashi K, Kakuda T. Antiobesity activity of extracts from Lagerstroemia speciosa L leaves on female KK-Ay mice. J Nutr Sci Vitaminol (Tokyo)1999;45(6):791–5.
Murakami C, Myoga K, Kasai R, Ohtani K, Kurokawa T, Ishibashi S, et al. Screening of plant constituents for effect on glucose transport activity in Ehrlich Ascites tumor cells. Chem Pharm Bull 1993;41(12):2129–31.
Hayashi T, Maruyama H, Kasai R, Hattori K, Takasuga S, Hazeki O, et al. Ellagitannins from Lagerstroemia speciosa as activators of glucose transport in fat cells. Planta Med 2002; 68(2):173–5.
Hattori K, Sukenobu N, Sasaki T, Takasuga S, Hayashi T, Kasai R, et al. Activation of insulin receptors by lagerstroemin. J Pharmacol Sci 2003;93(1):69–73.
Guy Klein1, Jaekyung Kim2, Klaus Himmeldirk3, Yanyan Cao4,5 and Xiaozhuo Chen1,2,4,5,Antidiabetes and Anti-obesity Activity of Lagerstroemia speciosa 1College of Osteopathic Medicine, 2Edison Biotechnology Institute, 3Department of Chemistry and Biochemistry, 4The Molecular and Cellular Biology Program, 5Department of Biological Science and 6Department of Biomedical Science, Ohio University, USA

The Science of Ginger

Ginger (Zingiber officinale) has been extensively studied for its metabolic and digestive benefits, making it an excellent complement to Banaba in your Lean formulation. The following scientific evidence supports ginger’s effectiveness for weight management and digestive health:

A comprehensive meta-analysis demonstrated that ginger intake significantly reduced body weight, waist-hip ratio, heart rate, fasting glucose, and insulin resistance markers (HOMA-IR), while increasing beneficial HDL-cholesterol levels[1].
Research published in the journal Metabolism found that ginger consumption enhances the thermic effect of food (TEF) by approximately 43 kcal/day, indicating increased calorie burning after meals[2].
The same study revealed that ginger significantly reduced subjective feelings of hunger (P=0.002) and prospective food intake (P=0.004), while increasing sensations of fullness (P=0.064) compared to control conditions[2].
Ginger contains bioactive compounds called gingerols and shogaols that stimulate various biological activities in the body, including antioxidant and anti-inflammatory effects that support overall metabolic health[3].
A 2019 scientific review concluded that ginger supplementation significantly reduced body weight, waist-hip ratio, and hip ratio in study participants[4].
Animal studies have shown that ginger significantly reduces body weight and systemic inflammation while lowering cholesterol and blood sugar levels[5].
Human studies using various ginger formulations (capsules, tablets, and powders) have consistently associated ginger consumption with weight loss in overweight adults[5].
Ginger has been linked to positive changes in multiple metabolic markers, including cholesterol, blood sugar, blood pressure, inflammatory proteins, and liver health[5].
Research indicates that ginger supports digestive health by stimulating digestion and easing gastrointestinal discomfort, which complements its weight management properties[3].
The thermogenic properties of ginger, combined with its appetite-suppressing effects, suggest a dual-action approach to weight management that works synergistically with Banaba’s blood sugar regulating effects[2][3].

These scientific findings strongly support the inclusion of ginger in your Lean formulation, highlighting its complementary role alongside Lagerstroemia speciosa (Banaba) for comprehensive weight management support.

Citations

[1] https://pubmed.ncbi.nlm.nih.gov/29393665/
[2] https://pmc.ncbi.nlm.nih.gov/articles/PMC3408800/
[3] https://www.healthline.com/health/ginger-for-weight-loss
[4] https://www.healthline.com/nutrition/11-proven-benefits-of-ginger
[5] https://time.com/collection/guide-to-weight-loss/4787027/ginger-body-fat-obesity/

Piper Mythisticum (aka Kava)

Piper methysticum (Kava): An Ancient Remedy for Modern Times

Introduction to Kava and Its Cultural Heritage

Kava, scientifically known as Piper methysticum, has been an integral part of Pacific Island culture for over 3,000 years. This plant, believed to have originated on the island of Maewo in Northern Vanuatu, has played a crucial role in religious rituals, formal gatherings, and family ceremonies. Traditionally, Kava is prepared from the root of the plant to create a drink that induces relaxation and promotes social interaction. Its calming effects have made it a staple in important cultural events, where it helps participants engage in conversation more easily and feel a deep sense of calm.

Phytochemical Composition and Therapeutic Properties

The therapeutic effects of Kava are attributed to a rich composition of bioactive compounds, including tannins, alkaloids, benzoic acid, cinnamic acid, and especially kavalactones. These kavalactones are primarily responsible for Kava’s anxiolytic (anti-anxiety), sedative, and neuroprotective properties. Research has shown that kavalactones interact with neurotransmitters in the brain such as GABA receptors to produce these calming effects. This has made Kava a popular natural remedy for anxiety, depression, and insomnia, offering an alternative to pharmaceutical interventions (Singh & Singh, 2002; Smith & Leiras, 2018).

Traditional and Modern Uses of Kava

Historically, Kava has been used in the Pacific Islands not only for its calming effects but also as a symbol of social and spiritual connection. The drink made from Kava roots holds deep symbolic meaning, with specific rules and rituals governing its preparation and consumption. In modern times, Kava’s benefits have been recognized beyond its cultural origins, gaining popularity worldwide as a natural remedy for various conditions, including anxiety, menopause symptoms, and sleep disturbances.

Phytochemical studies have identified at least 56 compounds in Kava, further highlighting its complex pharmacological profile. However, despite its benefits, Kava should be used with caution due to potential risks such as hepatotoxicity, particularly with certain extraction methods (Teschke et al., 2011; Teschke, Sarris, & Lebot, 2011).

Conclusion

Kava, or Piper methysticum, is a plant with a rich cultural heritage and significant therapeutic potential. Its ability to alleviate anxiety, promote relaxation, and support overall mental well-being makes it a valuable tool in both traditional and modern medicine. As research continues, Kava remains a powerful natural remedy, bridging ancient wisdom with contemporary health practices.

Singh, Y. N., & Singh, N. N. (2002). Therapeutic potential of kava in the treatment of anxiety disorders. CNS drugs, 16 (11), 731-743.
http://dx.doi.org/10.2165/00023210-200216110-00002 Smith, K., & Leiras, C. (2018). The effectiveness and safety of Kava Kava for treating anxiety symptoms: A systematic review and analysis of randomized clinical trials. Complementary therapies in clinical practice, 33, 107-117. http://dx.doi.org/10.1016/j.ctcp.2018.09.003
Smith, R. M. (1983). Kava lactones in Piper methysticum from Fiji. Phytochemistry, 22 (4), 1055-1056. https://doi.org/10.1016/0031-9422(83)85065-1
Smith, R. M., Thakrar, H., Arowolo, T., & Shafi, A. (1984). High-performance liquid chromatography of kava lactones from Piper methysticum. Journal of
Chromatography A, 283, 303-308. https://doi.org/10.1016/S0021-9673(00)96265-4 Terazawa, R., Akimoto, N., Kato, T., Itoh, T., Fujita, Y., Hamada, N., Deguchi, T., Iinuma, M., Noda, M., & Nozawa, Y. (2013) . A kavalactone derivative inhibits lipopolysaccharide-stimulated iNOS induction and NO production through activation of Nrf2 signaling in BV2 microglial cells. Pharmacological
Research, 71, 34-43. http://dx.doi.org/10.1016/j.phrs.2013.02.002 Teschke, R., Genthner, A., & Wolff, A. (2009). Kava hepatotoxicity: Comparison of aqueous, ethanolic, acetonic kava extracts and kava–herbs mixtures. Journal
of ethnopharmacology, 123 (3), 378-384. https://doi.org/10.1016/j.jep.2009.03.038 Teschke, R., Qiu, S. X., & Lebot, V. (2011). Herbal hepatotoxicity by kava: update on pipermethystine, flavokavain B, and mould hepatotoxins as primarily assumed culprits. Digestive and Liver Disease, 43 (9), 676-681. http://dx.doi.org/10.1016/j.dld.2011.01.018
Teschke, R., Sarris, J., & Lebot, V. (2011). Kava hepatotoxicity solution: A six-point plan for new kava standardization. Phytomedicine, 18 (2-3), 96-103. http://dx.doi.org/10.1016/j.phymed.2010.10.002
Thomsen, M., & Schmidt, M. (2021). Health policy versus kava (Piper methysticum): Anxiolytic efficacy may be instrumental in restoring the reputation of a major South Pacific crop. Journal of ethnopharmacology, 268, 113582. ttp://dx.doi.org/10.1016/j.jep.2020.113582
Tugcu, G., Kırmızıbekmez, H., & Aydın, A. (2020). The integrated use of in silico methods for the hepatotoxicity potential of Piper methysticum. Food and chemical toxicology, 145, 111663. http://dx.doi.org/10.1016/j.fct.2020.111663
Uddin, M. J., & Zidorn, C. (2020). Traditional herbal medicines against CNS disorders from Bangladesh. Natural Products and Bioprospecting, 10, 1-33. https://doi.org/10.1007/s13659-020-00269-7
Uebelhack, R., Franke, L., & Schewe, H. J. (1998). Inhibition of platelet MAO-B by kava pyrone-enriched extract from Piper methysticum Forster (kavakava).
Pharmacopsychiatry, 31 (05), 187-192. http://dx.doi.org/10.1055/s-2007-979325 Volgin, A., Yang, L., Amstislavskaya, T., Demin, K., Wang, D., Yan, D., Wang, J., Wang, M., Alpyshov, E., & Hu, G. (2020). DARK Classics in Chemical Neuroscience: Kava. ACS chemical neuroscience, 11 (23), 3893-3904. http://dx.doi.org/10.1021/acschemneuro.9b00587
Volz, H. P., & Kieser, M. (1997). Kava-kava extract WS 1490 versus placebo in anxiety disorders-a randomized placebo-controlled 25-week outpatient trial.
Pharmacopsychiatry, 30 (01), 1-5. https://doi.org/10.1055/s-2007-979474 Walden, J., Von Wegerer, J., Winter, U., Berger, M., & Grunze, H. (1997). Effects of kawain and dihydromethysticin on field potential changes in the hippocampus. Progress in neuro-psychopharmacology & biological psychiatry, 21 (4), 697-706. http://dx.doi.org/10.1016/s0278-5846(97)00042-0
Wang, D., Yang, L., Wang, J., Hu, G., Liu, Z., Yan, D., Serikuly, N., Alpyshov, E. T., Demin, K. A., & Galstyan, D. S. (2020). Behavioral and physiological effects of acute and chronic kava exposure in adult zebrafish. Neurotoxicology and teratology, 79, 106881. http://dx.doi.org/10.1016/j.ntt.2020.106881
Wong, A., & Townley, S. A. (2011). Herbal medicines and anaesthesia. Continuing Education in Anaesthesia. Critical Care and Pain, 11 (1), 14-17.
http://dx.doi.org/10.1093/bjaceaccp/mkq046 World Health Organization, Bangladesh (2021). https://www.searo.who.int/bangladesh/mental-health/en
Wruck, C. J., Götz, M. E., Herdegen, T., Varoga, D., Brandenburg, L. O., & Pufe, T. (2008). Kavalactones protect neural cells against amyloid β peptide-induced neurotoxicity via extracellular signal-regulated kinase 1/2-dependent nuclear factor erythroid 2-related factor 2 activation. Molecular Pharmacology, 73 (6),
1785-1795. http://dx.doi.org/10.1124/mol.107.042499 Yang, J. X (2019). A new kavalactone dimer from Piper methysticum. Chemistry of Natural Compounds, 55 (4), 606-609. https://doi.org/10.1007/s10600-019-
02759-8 Yang, X., & Salminen, W. F. (2011). Kava extract, an herbal alternative for anxiety relief, potentiates acetaminophen-induced cytotoxicity in rat hepatic cells.
Phytomedicine, 18 (7), 592-600. http://dx.doi.org/10.1016/j.phymed.2011.02.006 Yuan, C. S., Dey, L., Wang, A., Mehendale, S., Xie, J. T., Aung, H. H., & Ang-Lee, M. K. (2002). Kavalactones and Dihydrokavain Modulate GABAergic Activity in a Rat Gastric-Brainstem Preparation. Planta Medica, 68 (12), 1092-1096. http://dx.doi.org/10.1055/s-2002-36338

The Science of Blue Lotus

Blue lotus (Nymphaea caerulea), also known as the Egyptian blue water lily, has been used for centuries in traditional medicine, particularly in ancient Egypt, for its purported medicinal and psychoactive properties. It is often associated with spiritual rituals, relaxation, and mood enhancement. It is known for containing compounds like apomorphine and nuciferine, which are thought to have psychoactive effects.

. Key Compounds and Their Effects

Apomorphine: A dopamine agonist found in blue lotus, which can influence mood, motivation, and pleasure by stimulating dopamine receptors. Dopamine is crucial for regulating mood, and low levels are associated with depression and insomnia. However, the presence of apomorphine in blue lotus is debated, and its levels are not consistently confirmed in scientific analyses.
- Relevance: While apomorphine’s effects on dopamine could theoretically support mood enhancement, there are no studies directly linking blue lotus consumption to these effects in humans. For example, Health.com suggests it may treat depression and insomnia due to dopamine stimulation, but this is based on the compound’s known effects, not blue lotus-specific research.
Nuciferine: An alkaloid with antipsychotic properties, which may interact with neurotransmitter systems (e.g., dopamine and serotonin) to induce calmness and potentially alleviate symptoms of mental health conditions like depression and PTSD.
- Evidence: A study on nuciferine (PMC6222486) suggests it may have anti-inflammatory effects, which could be relevant to mental health since inflammation is linked to conditions like depression. However, this study does not directly address blue lotus or mental health outcomes, focusing instead on its anti-inflammatory potential in cell lines.
- Implication: While promising, this is indirect evidence, and more research is needed to confirm nuciferine’s effects from blue lotus on human mental health.
Antioxidants: Blue lotus contains flavonoids, quercetin, kaempferol, and myricetin, which have antioxidant properties. Antioxidants are associated with reducing oxidative stress, which can indirectly support mental health by protecting brain cells. However, no studies directly link blue lotus antioxidants to mental health benefits, as noted in Healthline.

Key Citations

Ginger and Nettle: A Powerhouse Duo for Vitality and Performance

Introduction to Ginger and Nettle

Ginger and Nettle are two potent natural ingredients that have been used in traditional medicine for centuries. Ginger, known for its vasodilating and antioxidant properties, stimulates the production of nitric oxide, which enhances blood flow and supports various health benefits, including increased testosterone levels. Nettle, a medicinal plant from the Urticaceae family, is rich in nutrients and has been used to treat numerous conditions, from inflammation to prostate health.

Phytochemical Composition and Health Benefits

Ginger, particularly Black Ginger (Kaempferia Parviflora), is packed with potent phytochemicals that contribute to its health-promoting effects. It boosts nitric oxide production, which dilates blood vessels, promotes nutrient delivery, and enhances muscle performance. Additionally, it has been shown to increase dopamine levels and inhibit PDE-5, mechanisms that contribute to enhanced sexual performance and stamina.

Stinging Nettle (Urtica dioica) is similarly powerful, offering a variety of vitamins, minerals, fatty acids, and antioxidants. It has anti-inflammatory properties, making it effective in reducing symptoms of conditions like arthritis. Moreover, Nettle is known for its ability to support prostate health, reduce blood pressure, and regulate blood sugar levels.

Traditional Uses and Modern Research

Both Ginger and Nettle have long histories of use in traditional medicine. Ginger has been utilized to improve circulation and boost energy, while Nettle has been used since ancient times to treat a wide range of ailments, including arthritis, anemia, and prostate issues. Modern research continues to validate these traditional uses, showing that these ingredients not only enhance physical performance and endurance but also contribute to better sexual health.

Conclusion

The combination of Ginger and Nettle offers a synergistic blend of benefits, from boosting physical endurance and sexual performance to reducing inflammation and supporting prostate health. Whether used individually or together, these ingredients provide a powerful, natural way to enhance overall vitality and well-being.

Mahluji S, Ostadrahimi AR, Mobasseri M, Ebrahimzade Attari V, Payahoo L. Anti-inflammatory effects of Zingiber Officinale in type 2 diabetic patients. Pharm. Bull. 2013;3:273–276. [PMC free article][PubMed] [Google Scholar]
Mahmoud AH, Motawa HM, Wahba He, Ebrahim EY. Study of Some Antioxidant Parameters in Mice Livers Affected with Urtica pilulifera Extracts. Asian J of Bioch. 2006;1:67–74. [Google Scholar]
Malekirad AA, Hosseini N, Bayrami M, Hashemi T, Rahzani K, Abdollahi M. Benefit of Lemon Verbena in Healthy Subjects; Targeting Diseases Associated with Oxidative Stress. Asian J Anim Vet Adv. 2011;6:953–957. [Google Scholar]
Malviya N, Jain S, Malviya S. Antidiabetic potential of medicinal plants. Acta Pol Pharm. 2010;67:113–118. [PubMed] [Google Scholar]
Mamta S, Preeti k. Urtica dioica (Stinging nettle): A review of its chemical, pharmacological, toxicological and ethnomedical properties. Int J Pharm. 2014;4:270–277. [Google Scholar]
Manohar SM, Vaikasuvu SR, Deepthi K, Sachan A, Pemmaraju SR, Narasimha VL. An association of hyperglycemia with plasma malondialdehyde and atherogenic lipid risk factors in newly diagnosed Type 2 diabetic patients. J Res Med Sci. 2013;18:89–93. [PMC free article][PubMed] [Google Scholar]
Marazioti A, Bucci M, Coletta C, Vellecco V, Baskaran P, Szabo C, Cirino G, Marques AN, Guerreiro B, Goncalves AML, Seixas JD, Beuve A, Romao CC, Papapetropoulos A. Inhibition of nitric oxide–stimulated vasorelaxation by carbon monoxide-releasing molecules. Arterioscler Thromb Vasc Biol. 2011;31:2570–2575. [PubMed] [Google Scholar]
Nassiri-Asl M, Zamansoltani F, Abbasi E, Daneshi MM, Zangivand AA. Effectsof Urtica dioica extract on lipid profile in hypercholesterolemic rats. Zhong XiYi Jie He Xue Bao. 2009;7:428–433. [PubMed] [Google Scholar]
Nahata A, Dixit AK. Ameliorative effects of stinging U. dioica (Urtica dioica) ontestosterone-induced prostatic hyperplasia in rats. Andrologia. 2012;44:396–409. [PubMed] [Google Scholar]
Nazemi N, Tarighat A, Bahrami A. The effect of hydro-alcoholic UD (Urtica dioica) extract on oxidative stress in patients with type 2 diabetes. A randomized double-blind clinical trial. Pak J Bio Sci. 2012;15:98–102. [PubMed] [Google Scholar]
Nojima H, Watanabe H, Yamane K, Kitahara Y, Sekikawa K, Yamamoto H, Yokoyama A, Inamizu T, Asahara T, Kohno N. Effect of aerobic exercise training on oxidative stress in patients with type 2 diabetes mellitus. Metabo Clini Exp. 2008;57:170–176. [PubMed] [Google Scholar]
Otles S, Yalcin B. Phenolic compounds analysis of root, stalk, and leaves of U. Sci World J. 2012;1:64–67. [Google Scholar]
Ozen T, Korkmaz H. Modulatory effect of Urtica dioica L (Urticaceae) leaf extract on biotransformation enzyme systems, antioxidant enzymes, lactate dehydrogenase and lipid peroxidation in mice. 2003;10:405–15. [PubMed] [Google Scholar]
Patience OO, Estella UO, Philip FU. The search for new hypoglycemic agents from plants. J. Pharm. Pharmacol. 2014;8:292–303. [Google Scholar]
Petal DK, Prasad SK, Hemalatha S. An overview on antidiabetic medicinal plants having insulin mimetic property. Asian Pac J Trop Biomed. 2012;2:320–330. [PMC free article][PubMed] [Google Scholar]
Patel SH, Udayabanu M. Effect of Urtica dioica on memory dysfunction and hypoalgesia in anexperimental model of diabetic neuropathy. Neuroscience Letters. 2013;552:114–119. [PubMed] [Google Scholar]
Pourahmadi M, Karimi Jashni H, Bagheri Mand, Sotoodeh Jahromi A. The effect of hydro-alcoholic extract of Urtica dioica Root on testes in adult rats. Life Sci. J. 2014;11:420–424. [Google Scholar]
Rains JL, Jain SK. Oxidative stress, insulin signaling and diabetes. Free Radical Biol Med. 2011;50:567–575. [PMC free article][PubMed] [Google Scholar]
Rasheed Z, Ahmad R, Rasheed N, Tripathi T, Ali R. Reactive oxygen species damaged hemoglobin present unique epitopes for type 1 diabetes autoantibodies. Int J Biol Chem. 2008;2:1–13. [Google Scholar]
Tessari P, Cecchet D, Cosma A, Vettore A, Coracina A, Millioni R, Iori E, Puricelli L, Avogaro A, Vedovato M. Nitric oxide synthesis is reduced in subjects with type 2 diabetes and nephropathy. 2010;59:2152–2159. [PMC free article] [PubMed] [Google Scholar]
Testai L, Chericoni S, Calderone V, Nencioni G, Nieri P, Morelli I, Martinotti E. Cardiovascular effects of Urtica dioica L (Urticaceae) roots extracts: in vitro and in vivo pharmacological studies. Ethnopharmacol. 2002;81:105–109. [PubMed] [Google Scholar]
Tong PCY, Cockrum CS. Diabetes and its historical and social context: The epidemiology of type2 diabetes. Textbook of Diabetes. 3. Massachusetts, USA: Blackwell Science Ltd. ; 2003. pp. 1–14. [Google Scholar]
Toldy A, Stadler K, Sasvari M, Jakus J, Jung KJ, Chung HY, Berkes I, Nyakas C, Radak Z. The effect of exercise and U dioica supplementation on oxidative stress markers in the rat brain. Brain Res Bull. 2005;65:487–493. [PubMed] [Google Scholar]
Turkdogan MK, Ozbek H, Yener Z, Tuncer I, Uygan I, Ceylan E. The role of Urtica dioica and Nigella sativa in the prevention of carbon tetrachloride induced hepatotoxicity in rats. 2003;17:942–946. [PubMed] [Google Scholar]

Rhodiola Rosea

Rhodiola Rosea: The Golden Root for Endurance and Vitality

Introduction to Rhodiola Rosea

Rhodiola Rosea, commonly known as Golden Root or Arctic Root, is a powerful adaptogen traditionally used in cold regions such as Scandinavia, Russia, and other parts of Northern Europe and Asia. For centuries, it has been celebrated for its ability to combat fatigue, increase physical endurance, and improve mental performance. Rhodiola’s rich history includes its use by Vikings to enhance physical and mental endurance during raids and its inclusion in the first Swedish pharmacopeia in 1755.

Phytochemical Composition and Health Benefits

The health benefits of Rhodiola Rosea are attributed to its active compounds, including rosavin, salidroside, and tyrosol. These compounds possess antioxidant, anti-inflammatory, and neuroprotective properties. As an adaptogen, Rhodiola helps the body adapt to various stressors, both physical and mental, by modulating the stress response system. This makes it effective in reducing fatigue, enhancing stamina, and improving cognitive function, memory, and concentration. Additionally, Rhodiola has been traditionally used to treat a range of conditions, including anxiety, depression, anemia, infections, and sexual dysfunction.

Traditional Uses and Modern Research

Rhodiola Rosea has a rich history in traditional medicine, where it was used to increase endurance, treat fatigue, and boost fertility. In an open study, Rhodiola significantly improved sexual function in men with erectile dysfunction and premature ejaculation. In Sweden, Rhodiola is recognized as an Herbal Medicinal Product and is widely used as a psychostimulant to increase mental work capacity during stress.

However, while Rhodiola has a long history of use, scientific research on its effects is still developing. Early studies have shown positive results in reducing fatigue and improving mental performance, but more research is needed to fully establish its efficacy and safety for various health conditions.

Conclusion

Rhodiola Rosea, the “Golden Root,” offers a wide range of health benefits, from enhancing physical endurance to reducing stress and improving mental clarity. Its potential to improve sexual health and overall vitality makes it a valuable addition to both traditional and modern wellness practices. As research continues to uncover the full extent of Rhodiola’s benefits, it remains a powerful tool for promoting endurance, resilience, and overall well-being.

Mattson MP, Pedersen WA, Duan W, Culmsee C, Camandola S. Cellular and molecular mechanisms underlying perturbed energy metabolism and neuronal degeneration in Alzheimer’s and Parkinson’s diseases. Ann N Y Acad Sci 1999;893:154-75.
Saratikov AS, Krasnov EA. Chapter III: Stimulative properties of Rhodiola rosea. In: Saratikov AS, Krasnov EA, editors. Rhodiola rosea is a valuable medicinal plant (Golden Root). Tomsk, Russia: Tomsk State University; 1987. p. 69-90.
Panossian A, Wikman G, Wagner H. Plant adaptogens. III. Earlier and more recent aspects and concepts on their mode of action. Phytomedicine 1999;6(4):287-300.
Salnik BU. Effect of several stimulators on central nervous system energy metabolism during muscular workload [dissertation]. Tomsk, Russia: Tomsk State Medical Institute; 1970.
Adamchuk LB. Effects of Rhodiola on the process of energetic recovery of rat under intense muscular workload [dissertation]. Tomsk, Russia: Tomsk State Medical Institute; 1969.
Danbueva EA. Effect of stimulators of the central nervous system on lipid metabolism at different muscular workloads [dissertation]. Tomsk, Russia: Tomsk State Medical Institute; 1968.
Revina TA. Effect of stimulators of the central nervous system on carbohydrate and high energy phosphorylated compound metabolism in the brain during intense muscular workload [dissertation] Tomsk, Russia: Tomsk State Medical Institute; 1969.
Brekhman II, Dardymov IV. New substances of plant origin which increase non-specific resistance. Ann Rev Pharmacol 1968;(9):419-30.
Porsolt RD, Anton G, Blavet N, Jalfre M. Behavioral despair in rats: a new model sensitive to antidepressant treatments. Eur J Pharmacol 1978;47(4):379-91.
Borsini F, Meli A. Is the forced swimming test a suitable model for revealing antidepressant activity? Psychopharmacology (Berl) 1988;94(2):147-60.
Willner P. The validity of animal models of depression. Psychopharmacology (Berl) 1984;83(1):1-16.
Boon-Niermeijer EK, van den Berg A, Wikman G, Wiegant FA. Phyto-adaptogens protect against environmental stress-induced death of embryos from the freshwater snail Lymnaea stagnalis. Phytomedicine 2000;7(5):389-99.
Lishmanov IuB, Trifonova ZhV, Tsibin AN, Maslova LV, Dementeva LA. Plasma beta-endorphin and stress hormones in stress and adaptation. Biull Eksp Biol Med 1987;103(4):422-4.
Maslova LV, Kondratev BIu, Maslov LN, Lishmanov IuB. The cardioprotective and antiadrenergic activity of an extract of Rhodiola rosea in stress. Eksp Klin Farmakol 1994;57(6):61-3.
Gerasimova HD. Effect of Rhodiola rosea extract on ovarian functional activity. Proc of Scientific Conference on Endocrinology and Gynecology. Sverdlovsk, Russia. 1970 Sept 15-16. Siberian Branch of the Russian Academy of Sciences. p. 46-8.
Saratikov AS, Krasnov EA. Chapter VI: The influence of Rhodiola on endocrine glands and the liver. In: Saratikov AS, Krasnov EA, editors. Rhodiola rosea is a valuable medicinal plant (Golden Root). Tomsk, Russia: Tomsk State University; 1987. p. 180-93.

ASHWAGANDA

The use of the medicinal herb Ashwagandha can be traced back to 6000 BC and its use in Ayurveda. Ayurveda is one of the oldest holistic health systems globally, and its roots are in India.

Ashwagandha has been known for thousands of years to relieve stress and anxiety and promote overall wellness and longevity. Research has also established that taking the herb increases sexual desire.

The plant itself is a small flowering shrub, but its power is the Ashwagandha root. The word Ashwagandha itself in Sanskrit means ‘smell of the horse’. The name could have been given 5trrrr44asbecause the shrub emits a strong smell and the fact that the plant can enhance your overall strength. In fact, ashwaganda’s use in Ayurvedic medicine extends back in time to the teachings of the most esteemed Hindu sages (rishis), Punarvasu Atreya. He is believed to have worked as the personal physician of the king. His teachings were the foundation for the Charaka.

The Science

The Science Behind Golden Showers Soap

Golden Showers Soap is formulated with several scientifically supported ingredients that contribute to skin health. Camel urine has been traditionally used in various cultures for its antimicrobial and anti-inflammatory properties. Research shows that the uric acid found in camel urine acts as a natural exfoliant, promoting the removal of dead skin cells and supporting skin renewal. This can be particularly beneficial for conditions such as psoriasis and eczema, where skin cell turnover is disrupted. Additionally, camel urine’s antimicrobial properties have been shown to inhibit the growth of bacteria and fungi, making it useful for maintaining a balanced skin microbiome.

Camel milk is rich in vitamins, minerals, and immunoglobulins, which help nourish the skin while also providing anti-inflammatory effects. The natural lactic acid in camel milk supports gentle exfoliation, while its high concentration of fatty acids enhances moisture retention, improving skin hydration and elasticity.

Hemp oil, derived from the seeds of the cannabis plant, is known for its high content of omega-3 and omega-6 fatty acids, which help in skin barrier repair and hydration. Studies have also highlighted hemp oil’s role in reducing inflammation and balancing the skin’s oil production, making it effective in soothing irritated skin.

Together, these ingredients contribute to the soap’s ability to enhance skin renewal, moisture retention, and the reduction of inflammation, providing a well-rounded approach to maintaining healthy skin.

Carbon 60 (C60)
Carbon 60 (C60) was an exciting find when it was discovered back in 1985. In fact, the scientists who found it were awarded the Nobel Prize in Chemistry in 1996 for the discovery.

Now, years later, C60 is still generating interest in research and medical communities.

The official name of C60 is buckminsterfullerene. C60 compounds are also casually referred to as buckyballs because of their round shape — and because the real name is quite a mouthful!

We’ve partnered with “C60 Purple Power” to explore frequently asked questions about C60.

Whether you know it as buckminsterfullerene, buckyballs, carbon 60, or C60, read on to get answers to some common questions about the compound.

C60 is a compound that’s being researched for a variety of medical, industrial, and scientific purposes. Because of its shape and stability, it’s been used as a tool to deliver drugs or genesTrusted Source in some animal and cell studies. When scientists discovered C60, they found a carbon compound made up of 60 carbon molecules that looks like a hollow cage shaped like a soccer ball. This shape gives it unique properties and allows it to hold materials inside. This is an area of interest for medical research. For example, according to a 2011 research review, C60’s hollow structure has been used in early research as a cage for HIV, making the virus unable to replicate itself.

There’s also interest in the antioxidant properties of C60. C60 readily grabs free radicals, which are associated with cell damage in the body. Research examining other potential medical or scientific uses for C60 is ongoing. Most research so far has been done in cells or animals, with few studies including humans.

Apex Turbo

Apex Turbo harnesses the power of two potent amino acids: L-Arginine and L-Citrulline. L-Arginine plays a crucial role in muscle metabolism and is a precursor for nitric oxide, a compound that relaxes blood vessels, increasing circulation and enhancing oxygen delivery to muscles. This improved blood flow supports endurance, strength, and faster recovery.

L-Citrulline complements L-Arginine by aiding in the removal of ammonia, a waste product of intense exercise. By clearing ammonia from the body, L-Citrulline reduces muscle fatigue and promotes quicker recovery, allowing for sustained high performance. Together, these ingredients form a powerhouse supplement designed to elevate your physical performance and stamina.

Apex Pulse

Apex Pulse leverages the combined power of enzymes and magnesium to offer comprehensive cardiovascular and digestive support. Serrapeptase, known for its potent anti-inflammatory properties, works synergistically with Nattokinase, a powerful fibrinolytic enzyme, to help maintain healthy blood flow and reduce plaque formation. Bromelains, derived from pineapple, further support digestion and anti-inflammatory processes, while Magnesium Orotate plays a key role in cellular energy production and muscle function. Together, these ingredients provide a multifaceted approach to improving cardiovascular health and digestive well-being.

Nettle + Black Ginger

Nettle – Stinging nettle (Urtica dioica) studies are showing that Nettle stimulates Nitric Oxide production ( https://pubmed.ncbi.nlm.nih.gov/27585814/ )

Stinging nettle is a nutritious plant popular in Western herbal medicine. It may reduce inflammation, hay fever symptoms, blood pressure and blood sugar levels — among other benefits.

Stinging nettle (Urtica dioica) has been a staple in herbal medicine since ancient times.

Ancient Egyptians used stinging nettle to treat arthritis and lower back pain, while Roman troops rubbed it on themselves to help stay warm (1).

Its scientific name, Urtica dioica, comes from the Latin word uro, which means “to burn,” because its leaves can cause a temporary burning sensation upon contact.

The leaves have hair-like structures that sting and also produce itching, redness and swelling. However, once it is processed into a supplement, dried, freeze-dried or cooked, stinging nettle can be safely consumed. Studies link it to a number of potential health benefits.

Stinging nettle offers a variety of vitamins, minerals, fatty acids, amino acids, polyphenols and pigments — many of which also act as antioxidants inside your body.

Stinging nettle may help suppress inflammation, which in turn could aid inflammatory
conditions, including arthritis.

Stinging nettle may help reduce prostate size and treat symptoms of an enlarged prostate gland in men with BPH

Stinging nettle may reduce hay fever symptoms. Yet, some research indicates that it may not be much more effective than a placebo.

Stinging nettle may help lower blood pressure by allowing your blood vessels to relax and reducing the force of your heart’s contractions.

Stinging nettle may help lower blood sugar levels.

Black ginger (Kaempferia Parviflora )

Aside from being a potent energy enhancer, Kaempferia Parviflora is also widely known for being a natural and effective libido enhancer. It boosts sexual function by inhibiting phosphodiesterase-5 (PDE-5) and increasing dopamine levels.
The presence of PDE-5 inhibitors increases nitric oxide availability in the penis, which results in harder, longer-lasting erections. (https://pubmed.ncbi.nlm.nih.gov/17113256/)

(Black Ginger Extract Enhances Physical Fitness Performance and Muscular Endurance. Kazuya Toda, Hiroshi Shimoda – Oryza Oil & Fat Chemical Co. Ltd., Ichinomiya, Japan Available online 11 August 2017, Version of Record 11 August 2017.)

Black ginger, the rhizome of Kaempferia parviflora (Zingiberaceae), has traditionally been used as a food and folk medicine for more than 1000 years in Thailand. Black ginger extract (K. parviflora extracts: KPE) is rich in polymethoxy flavonoids (PMF), which exhibit various bioactivities. In the present study, we examined the effects of KPE on physical fitness performance and muscular endurance and investigated the underlying mechanisms. In an in vitro test using C2C12 myoblasts, several PMF including 5,7-dimethoxyflavone improved muscular metabolism and suppressed muscular inflammatory responses. Physical fitness performance and muscular endurance were superior in mice orally administered KPE (45 mg/kg/day) for 4 weeks than in control mice. Moreover, KPE enhanced physical fitness, namely, grip strength, leg muscle strength, balance, endurance, and locomotor activity in athletes, the elderly, and healthy individuals. Therefore, KPE has the potential to enhance health in athletes and individuals with locomotive dysfunctions.

ASHWAGANDA

The use of the medicinal herb Ashwagandha can be traced back to 6000 BC and its use in Ayurveda. Ayurveda is one of the oldest holistic health systems globally, and its roots are in India.

Ashwagandha has been known for thousands of years to relieve stress and anxiety and promote overall wellness and longevity. Research has also established that taking the herb increases sexual desire.

The plant itself is a small flowering shrub, but its power is the Ashwagandha root. The word Ashwagandha itself in Sanskrit means ‘smell of the horse’. The name could have been given 5trrrr44asbecause the shrub emits a strong smell and the fact that the plant can enhance your overall strength. In fact, ashwaganda’s use in Ayurvedic medicine extends back in time to the teachings of the most esteemed Hindu sages (rishis), Punarvasu Atreya. He is believed to have worked as the personal physician of the king. His teachings were the foundation for the Charaka.

cart-new

Extracts

Multipacks

Supplements

Other Good Stuff

Guided Meditation

Free Product Immersions

cart-new

Eurycoma Longifolia (Tongkat Ali): Nature’s Powerhouse for Male Vitality

The Science Behind: “Apex-Alpha”

Self-Assessment

Your Primal Baseline: How Do You Feel Today?

Self-Assessment

Your Primal Baseline: How Do You Feel Today?

Self-Assessment

Your Primal Baseline: How Do You Feel Today?

Lagerstroemia speciosa (Banaba): The Queen’s Flower and Its Medicinal Potential

Ginger and Nettle: A Powerhouse Duo for Vitality and Performance

Rhodiola Rosea: The Golden Root for Endurance and Vitality

ASHWAGANDA

Carbon 60 (C60)
Carbon 60 (C60) was an exciting find when it was discovered back in 1985. In fact, the scientists who found it were awarded the Nobel Prize in Chemistry in 1996 for the discovery.

Now, years later, C60 is still generating interest in research and medical communities.

The official name of C60 is buckminsterfullerene. C60 compounds are also casually referred to as buckyballs because of their round shape — and because the real name is quite a mouthful!

We’ve partnered with “C60 Purple Power” to explore frequently asked questions about C60.

Whether you know it as buckminsterfullerene, buckyballs, carbon 60, or C60, read on to get answers to some common questions about the compound.

Apex Turbo

Apex Pulse